Prognostic factors in acute myelogenous leukemia

CXCR4 is a prognostic marker in acute myelogenous leukemia.

CXCR4 chemokine receptors retain hematopoietic progenitors and leukemia cells within the marrow microenvironment. We prospectively evaluated the prognostic implication of CXCR4 in 90 consecutive patients with acute myelogenous leukemia (AML) by flow cytometry. Patients were divided into groups with low (n=32), intermediate (n=26), or high (n=32) CXCR4 expression, as defined by CXCR4 mean fluore...

Familial Acute Myelogenous Leukemia: Report of Three Cases

Acute myelogenous leukemia (AML) is a hematological malignancy, which accounts for about 15-25% of childhood's leukemia. Genetic factor is one of the most important predisposing elements in childhood acute leukemia, especially AML. In this case report, a rare presentation of familial AML is presented in three monozygotic triplets. Two were 10 months old, and the other one was 16 months old at p...

Genetic Prognostic Factors in Acute Myeloid Leukemia

Acute Myelogenous Leukemia

Acute myeloid leukemia is not a single disease but a group of neoplastic disorders. The malignant cells gradually replace, and inhibit the growth and maturation of, normal erythroid, myeloid, and megakaryocytic precursors. Included among the names for this condition are acute myelogenous leukemia, acute myelocytic leukemia, acute myeloid leukemia, acute myeloblastic leukemia, acute granulocytic...

Acute Myelogenous Leukemia

Documented central nervous system (CNS) involvement in acute myelogenous leukemia (AML), unlike acute lymphocytic leukemia, is relatively uncommon [1 , 2] . CNS involvement in AML is reported to occur in 6%-17% of cases [1-4]. It is expected that improvements in therapy with increased frequency of remission and prolonged survival will lead to further increases in clinical CNS involvement in AML...